Non-invasive transdermal delivery of chemotherapeutic molecules in vivo using superparamagnetic iron oxide nanoparticles

Abstract Background The skin is both a target and potential conduit for the delivery of drugs, but its cornified cell layer resists penetration by most molecules. This study investigated superparamagnetic iron oxide nanoparticles to facilitate transdermal anticancer agents. Results Chemotherapeutic cancer drugs were applied with or without hairless mice, their ability penetrate was assessed using fluorescence microscopy tumor growth. Nanoparticles enhanced doxorubicin 5-fluorouracil as determined growth retardation experimental melanoma in immunocompetent, syngeneic mice. drug enhancement did not require conjugation encapsulation nanoparticles—simple co-administration sufficed. topically melanomas increased cytotoxicity immune infiltration induced co-administered 5-fluorouracil, also reduced vascularization tumors independently 5-fluorouracil. Conclusion Correctly formulated can chemotherapeutic effectiveness cytotoxic on increasing ameliorating host–tumor interactions. occurs need so will likely be applicable other also.